Simultaneous sensitive detection of multiple DNA glycosylases from lung cancer cells at the single-molecule level† †Electronic supplementary information (ESI) available: Molecular mechanism of the DNA glycosylase-mediated cleavage of molecular beacons and optimization of the experimental conditions. See DOI: 10.1039/c7sc04296e

Nucleic acid detection using BRET-beacons based on bioluminescent protein–DNA hybrids† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6cc10032e Click here for additional data file.

Bioluminescent molecular beacons have been developed using a modular design approach that relies on BRET between the bright luciferase NanoLuc and a Cy3 acceptor. While classical molecular beacons are hampered by background fluorescence and scattering, these BRET-beacons allow detection of low pM concentrations of nucleic acids directly in complex media.

Simultaneous impedance spectroscopy and fluorescence microscopy for the real-time monitoring of the response of cells to drugs† †Electronic supplementary information (ESI) available: Additional details on the simultaneous setup and mathematical modelling, control experiments on potential dye cytotoxicity, selecting the most sensitive frequency, XPS and electrochemical characterization of the modified surfaces. See DOI: 10.1039/c6sc05159f Click here for additional data file.

School of Chemistry, ARC Centre of Excelle Technology, University of New South Wa E-mail: [email protected] Australian Centre for NanoMedicine, Univ Wales 2052, Australia EMBL Australia Node in Single Molecule Advanced Molecular Imaging, University o 2052, Australia † Electronic supplementary information ( simultaneous setup and mathematical potential dye cytotoxicity, selecting the el...

Multiplexed DNA detection based on positional encoding/decoding with self-assembled DNA nanostructures† †Electronic supplementary information (ESI) available: Experimental details, additional DNA detection figures, and DNA sequence information. See DOI: 10.1039/c4sc02696a Click here for additional data file.

Fluorinated molecular beacons as functional DNA nanomolecules for cellular imaging† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc02819a Click here for additional data file.

Molecular Science and Biomedicine L Chemo/Bio-Sensing and Chemometrics, Engineering, College of Life Sciences, A Province, Hunan University, Changsha, Hu u.edu; ruowenwang@u.edu Department of Chemistry, Department of Ph for Research at the Bio/Nano Interface, Hea McKnight Brain Institute, University of Flori Department of Biotechnology and Biomed Tsinghua University, Zhejiang, 314006, Chi † E...

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells† †Electronic supplementary information (ESI) available: Experimental procedures and characterization of building blocks and pyridostatin analogues and FRET-melting profiles. See DOI: 10.1039/c2ob25830g Click here for additional data file.

The synthesis, biophysical and biological evaluation of a series of G-quadruplex interacting small molecules based on a N,N'-bis(quinolinyl)pyridine-2,6-dicarboxamide scaffold is described. The synthetic analogues were evaluated for their ability to stabilize telomeric G-quadruplex DNA, some of which showed very high stabilization potential associated with high selectivity over double-stranded ...